In Vitro Antioxidant Activity and in Vivo Wound-Healing Effect of Lecithin Liposomes: A Comparative Study Publisher Pubmed



Nasab ME¹ ; Takzaree N² ; Saffaria PM² ; Partoazar A^{1, 3}
Source: Journal of Comparative Effectiveness Research Published:2019

Abstract

Aim: This study was conducted to determine the potentials of egg lecithin (egg-l) and soy lecithin (soy-l) liposomes in antioxidative and wound healing properties. Materials & methods: The suspensions of egg-l and soy-l were prepared using the fusion technique. The free radical scavenging activity of both lecithin liposomes was evaluated by DPPH and ABTS methods. Tissue staining was used to assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend of 1-10 mg/ml in radical-scavenging activities (p < 0.0001). Wound-healing assessments showed a significant effect (p < 0.0001) in treatment with topical lecithin liposomes. The results of wound healing also showed better outcomes of egg-l in comparison with phenytoin 1% cream. Conclusion: Antioxidant lecithin liposomes may enhance the treatment of wound injuries. © 2019 Future Medicine Ltd.