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A New Approach to the Diagnosis and Treatment of Atherosclerosis: The Era of the Liposome Publisher Pubmed



Kiaie N1 ; Gorabi AM1 ; Penson PE2 ; Watts G3 ; Johnston TP4 ; Banach M5, 6 ; Sahebkar A7, 8, 9
Authors

Source: Drug Discovery Today Published:2020


Abstract

The consequences of atherosclerotic cardiovascular disease (ASCVD) include myocardial infarction, ischemic stroke, and angina pectoris, which are major causes of mortality and morbidity worldwide. Despite current therapeutic strategies to reduce risk, patients still experience the consequences of ASCVD. Consequently, a current goal is to enhance visualization of early atherosclerotic lesions to improve residual ASCVD risk. The uses of liposomes, in the context of ASCVD, can include as contrast agents for imaging techniques, as well as for the delivery of antiatherosclerotic drugs, genes, and cells to established sites of plaque. Additionally, liposomes have a role as vaccine adjuvants against mediators of atherosclerosis. Here. we review the scientific and clinical evidence relating to the use of liposomes in the diagnosis and management of ASCVD. This review describes the experimental and clinical evidence for the use of liposomes in the diagnosis and management of atherosclerotic cardiovascular disease. © 2019 Elsevier Ltd
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