Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels

Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels Publisher

Roohi A¹ ; Tabrizi M² ; Yaseri M³ ; Mohammadrezaei FM⁴ ; Nikbin B⁵

Source: Current Chemical Genomics and Translational Medicine Published:2018

Abstract

Background: Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation. Objective: In the present study, the association between low-density lipoprotein cholesterol (LDL-C) and interleukin 17A (IL-17A), as an inflammatory cytokine, was investigated. In addition to IL-17A, serum levels of interleukin 23 (IL-23) and transforming growth factor β (TGF-β), as effective cytokines in T helper 17 cell (Th17) development, were also determined. Method: Cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA) in healthy subjects with LDL-C<130 versus LDL-C=>130 mg/dL. Results: Although IL-17A is an inflammatory cytokine and a positive association between its levels and LDL-C is expected, the data obtained in this study provide support for a reverse association (p<0.05). Conclusion: Inflammation plays a major role in atherosclerosis development; however, various inflammatory components involved in atherosclerosis assert their own unique association with hypercholesterolemia. © 2018 Roohi et al.

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Style	Citing Format
MLA	Roohi A, et al.. "Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels." Current Chemical Genomics and Translational Medicine, vol. 12, no. , 2018, pp. 1-8.
APA	Roohi A, Tabrizi M, Yaseri M, Mohammadrezaei FM, Nikbin B (2018). Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels. Current Chemical Genomics and Translational Medicine, 12(), 1-8.
Chicago	Roohi A, Tabrizi M, Yaseri M, Mohammadrezaei FM, Nikbin B. "Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels." Current Chemical Genomics and Translational Medicine 12, no. (2018): 1-8.
Harvard	Roohi A et al. (2018) 'Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels', Current Chemical Genomics and Translational Medicine, 12(), pp. 1-8.
Vancouver	Roohi A, Tabrizi M, Yaseri M, Mohammadrezaei FM, Nikbin B. Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels. Current Chemical Genomics and Translational Medicine. 2018;12():1-8.
BibTex	@article{ author = {Roohi A and Tabrizi M and Yaseri M and Mohammadrezaei FM and Nikbin B}, title = {Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels}, journal = {Current Chemical Genomics and Translational Medicine}, volume = {12}, number = {}, pages = {1-8}, year = {2018} }
RIS	TY - JOUR AU - Roohi A AU - Tabrizi M AU - Yaseri M AU - Mohammadrezaei FM AU - Nikbin B TI - Healthy Adult Ldl-C Bears Reverse Association With Serum Il-17A Levels JO - Current Chemical Genomics and Translational Medicine VL - 12 IS - SP - 1 EP - 8 PY - 2018 ER -

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