Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Current and Future Perspectives of Pd-1/Pdl-1 Blockade in Cancer Immunotherapy Publisher Pubmed



Makuku R1, 3 ; Khalili N1, 2 ; Razi S1, 4 ; Keshavarzfathi M1, 2 ; Rezaei N3, 5, 6
Authors

Source: Journal of Immunology Research Published:2021


Abstract

Cancer immunotherapy, which reactivates weakened immune cells of cancer patients, has yielded great success in recent years. Among immunotherapeutic agents, immune checkpoint inhibitors have been of particular interest and have gained approval by the FDA for treatment of cancers. Immune checkpoint blockade through targeting programmed cell death protein-1 (PD-1) has demonstrated promising antitumor effects in cancer immunotherapy of many different solid and hematologic malignancies. However, despite promising results, a favorable response is observed only in a fraction of patients, and there is still lack of a single therapy modality with curative ability. In this paper, we review the current and future perspectives of PD-1/L1 blockade in cancer immunotherapy, with a particular focus on predictive biomarkers of response to therapy. We also discuss the adverse events associated with PD-1/L1/2 inhibitors, ranging from severe life-threatening conditions such as autoimmune myocarditis to mild and moderate reactions such as skin rashes, and explore the potential strategies for improving the efficacy of immunotherapy with PD-1/L1 checkpoint inhibitors. © 2021 Rangarirai Makuku et al.
Other Related Docs
4. Tumor Immunology, Clinical Immunology (2022)
11. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)
12. Biomarkers for Predicting the Outcome of Various Cancer Immunotherapies, Critical Reviews in Oncology/Hematology (2021)
18. Immune Checkpoint Inhibition in Covid-19: Risks and Benefits, Expert Opinion on Biological Therapy (2021)