Naringin-Loaded Poly(Ε-Caprolactone)/Gelatin Electrospun Mat As a Potential Wound Dressing: In Vitro and in Vivo Evaluation Publisher



Salehi M¹ ; Vaez A² ; Naserinosar M¹ ; Farzamfar S³ ; Ai A⁴ ; Ai J² ; Tavakol S⁵ ; Khakbiz M⁶ ; Ebrahimibarough S²
Source: Fibers and Polymers Published:2018

Abstract

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment. © 2018, The Korean Fiber Society and Springer Science+Business Media B.V., part of Springer Nature.