In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications

In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications Publisher Pubmed

Samadian H¹ ; Salehi M^{2, 3} ; Farzamfar S⁴ ; Vaez A⁴ ; Ehterami A⁵ ; Sahrapeyma H⁶ ; Goodarzi A⁴ ; Ghorbani S⁷

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2018

Abstract

The present study aimed to evaluate the efficacy of cellulose acetate/gelatin/nanohydroxyapatite (CA/Gel/nHA) nanocomposite mats as the wound dressing. The dressings were prepared with electrospinning of CA/Gel solutions containing 12.5, 25 and 50 mg nHA. The dressings were evaluated regarding their water uptake capacity, morphology, tensile strength, water vapour transmission rate, wettability and cellular response with L929 cell line. The results showed that the concentration of nHA had a direct correlation with porosity, water contact angle, water uptake, water vapor transmission rate and proliferation. In vivo studies showed that all dressings had higher wound closure percent than the sterile gauze, as the control. The highest wound closure value was achieved in the CA/Gel +25 mg nHA group, which showed 93.5 ± 1.6%. The histological and the histomorphometric examinations of the wounds revealed that the CA/Gel +25 mg nHA dressing had the greatest collagen synthesis, re-epithelialization, neovascularization and also the best cosmetic appearance. Based on our finding, it could be concluded the applicability of electrospun nanofibrous CA/Gel/nHA dressings for successful wound treatment. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

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Mahmoud Azami (3)

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Style	Citing Format
MLA	Samadian H, et al.. "In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications." Artificial Cells# Nanomedicine and Biotechnology, vol. 46, no. sup1, 2018, pp. 964-974.
APA	Samadian H, Salehi M, Farzamfar S, Vaez A, Ehterami A, Sahrapeyma H, Goodarzi A, Ghorbani S (2018). In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications. Artificial Cells# Nanomedicine and Biotechnology, 46(sup1), 964-974.
Chicago	Samadian H, Salehi M, Farzamfar S, Vaez A, Ehterami A, Sahrapeyma H, Goodarzi A, Ghorbani S. "In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications." Artificial Cells# Nanomedicine and Biotechnology 46, no. sup1 (2018): 964-974.
Harvard	Samadian H et al. (2018) 'In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications', Artificial Cells# Nanomedicine and Biotechnology, 46(sup1), pp. 964-974.
Vancouver	Samadian H, Salehi M, Farzamfar S, Vaez A, Ehterami A, Sahrapeyma H, et al.. In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications. Artificial Cells# Nanomedicine and Biotechnology. 2018;46(sup1):964-974.
BibTex	@article{ author = {Samadian H and Salehi M and Farzamfar S and Vaez A and Ehterami A and Sahrapeyma H and Goodarzi A and Ghorbani S}, title = {In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {46}, number = {sup1}, pages = {964-974}, year = {2018} }
RIS	TY - JOUR AU - Samadian H AU - Salehi M AU - Farzamfar S AU - Vaez A AU - Ehterami A AU - Sahrapeyma H AU - Goodarzi A AU - Ghorbani S TI - In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications JO - Artificial Cells# Nanomedicine and Biotechnology VL - 46 IS - sup1 SP - 964 EP - 974 PY - 2018 ER -

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