Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles

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Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles Publisher Pubmed

Mahmoudi M^{1, 2} ; Sheibani S³ ; Milani AS⁴ ; Rezaee F^{5, 6} ; Gauberti M⁷ ; Dinarvand R¹ ; Vali H³

Source: Nanomedicine Published:2015

Abstract

Aims: We aimed to investigate the physicochemical effects of superparamagnetic iron oxide nanoparticles (SPIONs) on the composition of the protein corona and their correspondence toxicological issues. Materials & methods: SPIONs of different sizes and surface charges were exposed to fetal bovine serum. The structure/composition and biological effects of the protein corona-SPION complexes were probed. Results & discussion: The affinity and level of adsorption of specific proteins is strongly dependent on the size and surface charge of the SPIONs. In vivo experiments on the mouse blood-brain barrier model revealed that nontargeted SPIONs containing specific proteins will enter the brain endothelial barrier cells. Conclusion: Some commercially available nanoparticles used for target-specific applications may have unintended uptake in the body (e.g., brain tissue) with potential cytotoxity. © 2015 Future Medicine Ltd.

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Style	Citing Format
MLA	Mahmoudi M, et al.. "Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles." Nanomedicine, vol. 10, no. 2, 2015, pp. 215-226.
APA	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, Vali H (2015). Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles. Nanomedicine, 10(2), 215-226.
Chicago	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, Vali H. "Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles." Nanomedicine 10, no. 2 (2015): 215-226.
Harvard	Mahmoudi M et al. (2015) 'Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles', Nanomedicine, 10(2), pp. 215-226.
Vancouver	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, et al.. Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles. Nanomedicine. 2015;10(2):215-226.
BibTex	@article{ author = {Mahmoudi M and Sheibani S and Milani AS and Rezaee F and Gauberti M and Dinarvand R and Vali H}, title = {Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles}, journal = {Nanomedicine}, volume = {10}, number = {2}, pages = {215-226}, year = {2015} }
RIS	TY - JOUR AU - Mahmoudi M AU - Sheibani S AU - Milani AS AU - Rezaee F AU - Gauberti M AU - Dinarvand R AU - Vali H TI - Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles JO - Nanomedicine VL - 10 IS - 2 SP - 215 EP - 226 PY - 2015 ER -

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