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Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles Publisher Pubmed



Mahmoudi M1, 2 ; Sheibani S3 ; Milani AS4 ; Rezaee F5, 6 ; Gauberti M7 ; Dinarvand R1 ; Vali H3
Authors

Source: Nanomedicine Published:2015


Abstract

Aims: We aimed to investigate the physicochemical effects of superparamagnetic iron oxide nanoparticles (SPIONs) on the composition of the protein corona and their correspondence toxicological issues. Materials & methods: SPIONs of different sizes and surface charges were exposed to fetal bovine serum. The structure/composition and biological effects of the protein corona-SPION complexes were probed. Results & discussion: The affinity and level of adsorption of specific proteins is strongly dependent on the size and surface charge of the SPIONs. In vivo experiments on the mouse blood-brain barrier model revealed that nontargeted SPIONs containing specific proteins will enter the brain endothelial barrier cells. Conclusion: Some commercially available nanoparticles used for target-specific applications may have unintended uptake in the body (e.g., brain tissue) with potential cytotoxity. © 2015 Future Medicine Ltd.
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