Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces Publisher Pubmed



Hajipour MJ^{1, 2, 3} ; Ghasemi F⁴ ; Aghaverdi H² ; Raoufi M^{2, 5} ; Linnef U⁶ ; Atyabi F² ; Nabipour I¹ ; Azhdarzadeh M² ; Derakhshankhah H⁷ ; Lotfabadi A⁷ ; Bargahi A¹ ; Alekhamis Z² ; Aghaie A⁸ ; Hashemi E⁹ Show All Authors
Source: Journal of Alzheimer's Disease Published:2017

Abstract

It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP complexes, obtained from different human serums, had distinct protein composition, including some specific proteins that are known as AD and MS biomarkers. The colorimetric responses, analyzed by chemometrics and statistical methods, demonstrate promising capabilities of the technology to unambiguously identify and discriminate AD and MS. The developed colorimetric technology might enable a simple, inexpensive and rapid detection/discrimination of neurodegenerative diseases. © 2017 - IOS Press and the authors.