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Application of Nano-Radiosensitizers in Combination Cancer Therapy Publisher



Varzandeh M1 ; Sabouri L2, 3 ; Mansouri V3, 4 ; Gharibshahian M3, 5 ; Beheshtizadeh N3, 6 ; Hamblin MR7, 8 ; Rezaei N8, 9, 10
Authors

Source: Bioengineering and Translational Medicine Published:2023


Abstract

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects. © 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
1. X-Ray-Based Cancer Diagnosis and Treatment Methods, Electromagnetic Waves-Based Cancer Diagnosis and Therapy: Principles and Applications of Nanomaterials (2023)
2. Critical Parameters to Translate Gold Nanoparticles As Radiosensitizing Agents Into the Clinic, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2023)
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