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Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties Publisher Pubmed



Beik J1 ; Alamzadeh Z1 ; Mirrahimi M1 ; Sarikhani A1 ; Ardakani TS2 ; Asadi M1 ; Irajirad R1 ; Mirrahimi M1 ; Mahabadi VP4, 5 ; Eslahi N6 ; Bulte JWM7, 8 ; Ghaznavi H9 ; Shakerizadeh A1
Authors

Source: ACS Applied Bio Materials Published:2021


Abstract

The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy. © 2021 American Chemical Society.
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