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Triple Combination of Heat, Drug and Radiation Using Alginate Hydrogel Co-Loaded With Gold Nanoparticles and Cisplatin for Locally Synergistic Cancer Therapy Publisher Pubmed



Mirrahimi M1 ; Beik J1 ; Mirrahimi M1 ; Alamzadeh Z1 ; Teymouri S1 ; Mahabadi VP3, 4 ; Eslahi N5 ; Ebrahimi Tazehmahalleh F6 ; Ghaznavi H7 ; Shakerizadeh A1 ; Moustakis C8
Authors

Source: International Journal of Biological Macromolecules Published:2020


Abstract

Although multimodal cancer therapy has shown superior antitumor efficacy in comparison to individual therapy due to the potential generation of synergistic interactions among the treatments, its clinical usage is highly hampered by systemic dose-limiting toxicities. Herein, we developed a multi-responsive nanocomplex constructed from alginate hydrogel co-loaded with cisplatin and gold nanoparticles (AuNPs) (abbreviated as ACA) to combine chemotherapy, radiotherapy (RT) and photothermal therapy. The nanocomplex markedly improved the efficiency of drug delivery where ACA resulted in noticeably higher tumor growth inhibition than free cisplatin. The tumor treated with ACA showed an increased heating rate upon 532 nm laser irradiation, indicating the photothermal conversion ability of the nanocomplex. While RT alone resulted in slight tumor growth inhibition, thermo-chemo therapy, chemoradiation therapy and thermo-radio therapy using ACA dramatically slowed down the rate of tumor growth. Upon 532 nm laser and 6 MV X-ray, the nanocomplex could enable a trimodal thermo-chemo-radio therapy that yielded complete tumor regression with no evidence of relapse during the 90-days follow up period. The results of this study demonstrated that the incorporation of AuNPs and cisplatin into alginate hydrogel network can effectively combine chemotherapy, RT and photothermal therapy to achieve a locally synergistic cancer therapy. © 2020 Elsevier B.V.
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