Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Up-Regulation of Rip1 and Ips-1 in Chronic Hbv Infected Patients Publisher



Safariarababadi M1 ; Modarressi MH1, 2 ; Arababadi MK3, 4
Authors

Source: Genetics and Molecular Biology Published:2019


Abstract

IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma. © 2019, Sociedade Brasileira de Genetica. Printed in Brazil.
Other Related Docs
7. Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine, Iranian Journal of Allergy# Asthma and Immunology (2015)
12. Role of Th1/Th2 Cells and Related Cytokines in Autoimmune Hepatitis, Turkish Journal of Gastroenterology (2017)