Iron Metabolism in Rheumatic Diseases

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Summary: Iron woes in arthritis? Review links dysregulated iron to RA, SLE via ROS, NETosis. Research suggests disease role. Joint clue? #RheumaticDiseases #IronMetabolism

Givian A^{1, 2} ; Azizan A^{1, 3} ; Jamshidi A¹ ; Mahmoudi M^{1, 3} ; Farhadi E^{1, 3}

Source: Journal of Translational Autoimmunity Published:2025

Abstract

Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired. Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression. © 2025 The Authors

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Style	Citing Format
MLA	Givian A, et al.. "Iron Metabolism in Rheumatic Diseases." Journal of Translational Autoimmunity, vol. 10, no. , 2025, pp. -.
APA	Givian A, Azizan A, Jamshidi A, Mahmoudi M, Farhadi E (2025). Iron Metabolism in Rheumatic Diseases. Journal of Translational Autoimmunity, 10(), -.
Chicago	Givian A, Azizan A, Jamshidi A, Mahmoudi M, Farhadi E. "Iron Metabolism in Rheumatic Diseases." Journal of Translational Autoimmunity 10, no. (2025): -.
Harvard	Givian A et al. (2025) 'Iron Metabolism in Rheumatic Diseases', Journal of Translational Autoimmunity, 10(), pp. -.
Vancouver	Givian A, Azizan A, Jamshidi A, Mahmoudi M, Farhadi E. Iron Metabolism in Rheumatic Diseases. Journal of Translational Autoimmunity. 2025;10():-.
BibTex	@article{ author = {Givian A and Azizan A and Jamshidi A and Mahmoudi M and Farhadi E}, title = {Iron Metabolism in Rheumatic Diseases}, journal = {Journal of Translational Autoimmunity}, volume = {10}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Givian A AU - Azizan A AU - Jamshidi A AU - Mahmoudi M AU - Farhadi E TI - Iron Metabolism in Rheumatic Diseases JO - Journal of Translational Autoimmunity VL - 10 IS - SP - EP - PY - 2025 ER -