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Comparing Safety of Heparin As Continuous Intravenous Infusion and Multiple Subcutaneous Injections Publisher Pubmed



Izadpanah M1 ; Khalili H1 ; Mohammadi M2
Authors

Source: Journal of Comparative Effectiveness Research Published:2016


Abstract

Aim: In this study, safety of two methods of unfractionated heparin administration for venous thromboembolism prophylaxis was compared in critically ill surgical patients. Methods: A total of 50 surgical critically ill patients randomly assigned to either subcutaneous unfractionated heparin 5000 units three-times a day or continuous intravenous infusion; 625 IU/h. During the intensive care unit (ICU) stay, patients' hemodynamic parameters, laboratory tests, symptoms and signs of thrombosis and bleeding were monitored closely. Results: During the patients' follow-up, no episode of bleeding or venous thromboembolism event was recorded. The differences in ICU and hospital stays were not significantly different between the groups. Conclusion: There are limited evidences regarding safety and efficacy of continuous intravenous infusion of unfractionated heparin for thromboprophylaxis. © 2016 Future Medicine Ltd.
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