Comparing Effects of Different Routes of Heparin Administration on the Serum Biomarkers of Thrombosis Publisher Pubmed



Izadpanah M¹ ; Mohammadi M² ; Khalili H³ ; Faramarzi MA⁴
Source: Journal of Comparative Effectiveness Research Published:2016

Abstract

Background: Association between thrombosis pathogenesis and inflammatory conditions has been reported. Also inflammatory biomarkers have been proposed for prediction of thrombosis events. Objectives: Effects of different methods of heparin administration (subcutaneous vs continuous infusion) as thromboprophylaxis on the biomarkers of thrombosis have been evaluated. Methods: Serum levels of hsCRP, IL-10 and P-selectin as the biomarkers of thrombosis were measured at baseline, days 3 and 7 during the patients' hospitalization period. Results: Changes in the serum levels of thrombosis biomarkers (hsCRP, IL-10 and P-selectin) were comparable between the subcutaneous and continuous infusion groups. Conclusion: Both subcutaneous injection and continuous infusion of heparin as thromboprophylaxis showed same effects on the thrombosis biomarkers. © 2016 Future Medicine Ltd.