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Potential Roles of Lncrna-Xist/Mirnas/Mrnas in Human Cancer Cells Publisher Pubmed



Farzaneh M1 ; Nasrolahi A2 ; Ghaedrahmati F3 ; Masoodi T4 ; Najafi S5 ; Sheykhisabzehpoush M6 ; Dari MAG7 ; Radoszkiewicz K8 ; Uddin S9 ; Azizidoost S10 ; Khoshnam SE11
Authors

Source: Clinical and Translational Oncology Published:2023


Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers. © 2023, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).
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