Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Functions, Mechanisms, and Clinical Applications of Lncrna Linc00857 in Cancer Pathogenesis Publisher Pubmed



Aldayyeni H1 ; Hjazi A2 ; Shahab S3 ; Gupta J4 ; Alsaab HO5 ; Motea YH6 ; Alazbjee AAA7 ; Romeroparra RM8 ; Obaid RF9 ; Hussien BM10 ; Hosseinifard SR11
Authors

Source: Human Cell Published:2023


Abstract

Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial–mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications. © 2023, The Author(s) under exclusive licence to Japan Human Cell Society.
Other Related Docs
12. Long Noncoding Rnas Biomarker-Based Cancer Assessment, Journal of Cellular Physiology (2019)
17. Linc01614: A Potential Therapeutic Target in Astrocytoma Progression, Journal of Cellular and Molecular Medicine (2025)
18. Long Non-Coding Rna Snar Promotes Proliferation in Egfr Wild Type Non-Small Cell Lung Cancer Cells, International Journal of Molecular and Cellular Medicine (2021)