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Clinical Assessment of Novel Nanofibrous Dressings for Cutaneous Leishmaniasis: A Trial-Based Study Publisher

Summary: Pilot trial demonstrates amphotericin B-loaded nanofibrous dressings promote healing in cutaneous leishmaniasis, offering a less toxic alternative. #Leishmaniasis #WoundHealing

Bagheri A1 ; Norouzi MR1 ; Ghasemimobarakeh L1 ; Hejazi SH2 ; Fesharaki M3
Authors

Source: Polymers for Advanced Technologies Published:2024


Abstract

The burden of cutaneous leishmaniasis, characterized by skin lesions from Leishmania parasites, has prompted a shift from traditional antimonial treatments to alternative therapies due to concerns over drug resistance and toxicity. This study heralds a novel multi-layered wound dressing embedded with amphotericin B (AMB) in polyvinyl alcohol (PVA) nanofibers, designed to deliver controlled drug release. Fabrication involved conventional and needleless electrospinning, with the latter producing nanofibers (N-PVA-AMB) with a larger diameter of 550 nm compared to 230 nm for conventional (PVA-AMB), resulting in a more sustained release of 55% over 65% for PVA-AMB after 50 min. A pilot clinical trial demonstrated significant healing in patients with non-healing ulcers within 4 weeks of treatment using the AMB-loaded dressing. The dressing's unique composition not only facilitates painless application but also promotes efficient moisture transfer, enhancing wound healing and providing a barrier against infection. This innovative dressing addresses the challenges of pain during dressing changes and microbial contamination, marking a significant advancement in cutaneous leishmaniasis treatment and offering a practical alternative to conventional therapies. © 2024 John Wiley & Sons Ltd.
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