A Novel Wound Dressing Nanofiber With Anti-Inflammatory and Anti-Bacterial Drugs Release for Skin Wound Healing Publisher

Summary: Study develops PGS/PHB fiber dressing loaded with drugs to fight infection and aid healing in burns and diabetic wounds. #WoundCare #Biomaterials

Heydari P¹ ; Zargarkharazi A² ; Varshosaz J³
Source: Journal of Isfahan Medical School Published:2019

Abstract

Background: The skin is always damaged by burns, physical damages, and diseases such as diabetes mellitus. Infection and acute inflammation of wounds caused by burns and diabetes ulcers lead to extensive damage and death. Therefore, it is necessary the design polymeric dressings containing drugs with controlling ability to release the drugs in wound site. Methods: Wound dressing of poly(glycerol sebacate) (PGS)/ polyhydroxybutyrate (PHB) was fabricated by coaxial electrospinning process. These fibers were characterized by scanning electron microscope (SEM) images. The anti-bacterial activity, cell viability (MTT) and cell adhesion were investigated. Findings: The results of SEM showed that the wound fibers were uniform, and with a diameter of 575 ± 40.6 nm. The drugs loaded were separately in the core and shell of fibers. The samples containing drugs showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Result of MTT did not show viability, attachment, and growth of cells in wound dressing with drugs. Conclusion: It can be concluded that this wound dressing with the release of two drugs simultaneously is an ideal wound dressing to control the infection, and heal the wound. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.