Executive Functions Are Related to Serum Testosterone and Basal Metabolism Rate Fluctuation But Not Lymphocyte Dopamine Receptor Expression in the Young Healthy Participants



Sadatshirazi MS^{1, 2} ; Ashabi G³ ; Babhadiashar N² ; Hessari MB⁴ ; Vousooghi N^{1, 2} ; Zarrindast MR^{2, 5}
Source: Physiology and Pharmacology (Iran) Published:2018

Abstract

Introduction: Herein, we evaluated linkages between executive functions (EFs) performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants. Results: Data showed there are no differences between two groups in Na+, K+, glucose, urea, creatinine, glutamic pyruvic transaminase, glutamic-oxaloacetic transaminase and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05). Conclusion: Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults. © 2018, Iranian Society of Physiology and Pharmacology. All rights reserved.