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Potential Biomarkers of Addiction Identified by Real-Time Pcr in Human Peripheral Blood Lymphocytes: A Narrative Review Publisher Pubmed



Nazari S1 ; Pourmand SM2 ; Makki SM3 ; Brand S4, 5, 6, 7, 8 ; Vousooghi N9, 10, 11
Authors

Source: Biomarkers in Medicine Published:2022


Abstract

Addiction-related neurobiological factors could be considered as potential biomarkers. The concentration of peripheral biomarkers in tissues like blood lymphocytes may mirror their brain levels. This review is focused on the mRNA expression of potential addiction biomarkers in human peripheral blood lymphocytes (PBLs). PubMed, EMBASE, Web of Science, Scopus and Google Scholar were searched using the keywords addiction', biomarker', peripheral blood lymphocyte', gene expression' and real-time PCR'. The results showed the alterations in the regulation of genes such as dopamine receptors, opioid receptors, NMDA receptors, cannabinoid receptors, α-synuclein, DYN, MAO-A, FosB and orexin-A as PBLs biomarkers in addiction stages. Such variations could also be found during abstinence and relapse. PBLs biomarkers may help in drug development and have clinical implications. © 2022 Future Medicine Ltd.
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