Hotair Expression As a Biomarker in Glioblastoma Multiforme: A Comprehensive Meta-Analysis of Current Evidence Publisher Pubmed



Bahranian A^{1, 2} ; Koshki M³ ; Farahmandi F^{1, 2} ; Eftekharian K⁴ ; Hemmati S⁵ ; Sattari M⁵ ; Zali A² ; Panahi G⁵
Source: Biomarkers in Medicine Published:2025

Abstract

Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM. Methods: We searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses. Results: The meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8–10.8, p = 0.00). Considerable heterogeneity was observed (Q-value: 1174.2, df = 9, I2 = 99.2%, p = 0.00). Subgroup analyses indicated significant associations in tissue samples and studies from the USA and China. Meta-regression revealed that study design and country contributed to the observed heterogeneity, with no significant publication bias detected. Conclusion: This analysis confirms the significant link between HOTAIR expression and GBM, highlighting HOTAIR as a potential therapeutic target and biomarker. Further research is necessary to clarify the biological mechanisms involved in this association. © 2025 Informa UK Limited, trading as Taylor & Francis Group.