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State of the Neoadjuvant Therapy for Glioblastoma Multiforme—Where Do We Stand? Publisher

Summary: Glioblastoma’s tough fight! Review finds neoadjuvant therapies underexplored vs other cancers; chemoradiotherapy standard fails to boost survival. Study calls for new pre-surgery trials. Hope for GBM? #Glioblastoma #NeuroOncology

Nabian N1, 2 ; Ghalehtaki R1, 2 ; Zeinalizadeh M3 ; Balana C4 ; Jablonska PA5
Authors

Source: Neuro-Oncology Advances Published:2024


Abstract

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Despite several investigations in this field, maximal safe resection followed by chemoradiotherapy and adjuvant temozolomide with or without tumor-treating fields remains the standard of care with poor survival outcomes. Many endeavors have failed to make a dramatic change in the outcomes of GBM patients.This study aimed to review the available strategies for newly diagnosed GBM in the neoadjuvant setting, which have been mainly neglected in contrast to other solid tumors. © The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
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