Nanotechnology-Based Theranostic Approaches in Brain Diseases Publisher



Masoudifar R¹ ; Moezzi SMI¹ ; Shahrbabak SM¹ ; Ahmadi M^{2, 3} ; Hajihosseini S¹ ; Anvari Z⁴ ; Saadati S⁴ ; Pouyanfar N⁴ ; Ghorbanibidkorpeh F⁴
Source: Theranostics Nanomaterials in Drug Delivery Published:2024

Abstract

Brain disorders pose significant challenges owing to the blood-brain barrier (BBB), which presents a formidable obstacle to the delivery of therapeutic or diagnostic agents, impeding their access to specific target areas within the brain. Therefore, it is pivotal to constantly monitor the progress of brain diseases or the effectiveness of the treatment. However, constant imaging is tiresome and time-consuming for patients and physicians alike. Thus, the imaging agents should be co-delivered with the therapeutics to demonstrate a theranostic process that can be more efficient and straightforward in clinical application. Nanotechnology, which entails the science of submicron materials, is a means to hinder the issues accompanied by consuming conventional drugs, problems such as adverse drug reactions, or the drug reaching unwanted sites. The nano-sized carriers can engulf the theranostic agents and deliver more effectively. Using nanotechnology is also beneficial in setting up useful theranostic programs for patients. Theranostics can be applied in various brain diseases with the assistance of systems in the nano range to gain maximum benefit from both wings of a suitable treatment. Hence, within the confines of this book chapter, we aimed to expound upon the nano-based theranostic approaches employed in the context of neurological and brain disorders. © 2025 Elsevier Inc. All rights reserved.