Advancements in Nanotechnology for Enhancing Dental Implant Integration and Root Regeneration Publisher



Khaneshi N ; Rostami M ; Mirkhani MS ; Izadi A ; Rowshani A ; Bidgoli MH
Source: Nanomedicine Research Journal Published:2025

Abstract

This review comprehensively explores the transformative role of nanotechnology in advancing dental implant integration and root regeneration. It highlights how nanoscale modifications of implant surfaces and incorporation of nanomaterials enhance osseointegration by promoting osteoblast adhesion and mimicking natural bone processes. The review discusses surface engineering techniques, antimicrobial nanoparticle coatings, and their clinical implications in infection control and implant longevity. Furthermore, it examines nanotechnology-driven approaches to root regeneration, including biomimetic scaffolds, stem cell delivery, and controlled growth factor release, which collectively stimulate effective tissue repair and regeneration. Advanced therapeutic strategies such as gene therapy using nanocarriers and smart nanomaterials offer promising directions for precision and multifunctionality in dental treatments. The review also addresses critical challenges related to safety, biocompatibility, regulation, and cost-effectiveness that must be overcome for clinical translation. Ultimately, it provides a forward-looking perspective on integrating nanotechnology with emerging biomedical technologies to revolutionize dental care, improve clinical outcomes, and promote sustainable practices. © 2025 Tehran University of Medical Sciences. All rights reserved.