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Vitamin D Supplementation Up-Regulates Il-6 and Il-17A Gene Expression in Multiple Sclerosis Patients Publisher Pubmed



Naghavi Gargari B1 ; Behmanesh M1 ; Shirvani Farsani Z1 ; Pahlevan Kakhki M1 ; Azimi AR2
Authors

Source: International Immunopharmacology Published:2015


Abstract

Abstract Vitamin D regulates gene expression and affects target cell functions. IL-6 and IL-17A are pro-inflammatory cytokines associated with MS pathogenesis. The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. Also, we performed a correlation analysis between the gene expression and some clinical features such as serum level of vitamin D and the expanded disability status scale (EDSS). Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment. Also, some gender specific correlations between the gene expression with vitamin D levels were detected in female RR-MS patients. © 2015 Elsevier B.V.
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