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Fat Soluble Vitamins in the Ocular, Cardiac, and Infectious Diseases: Myths and Misconceptions Publisher



Z Sepehri ZAHRA ; A Sargazi ALIYEH ; M Yousei MAYSAM ; F Sarhaddi FARKHONDE ; M Sepehri MEHDI ; A Behzadi ANAHITA ; S Etemadi SINA ; M Hedayatipour MARJAN ; Ya Moghaddam Yeganeh AZHDARI ; Nj Aghdam Nima JAVADI
Authors

Source: Advances in Biochemistry in Health and Disease Published:2024


Abstract

Fat-soluble vitamins have a pivotal role in in maintaining good vision and overall eye health. Profound importance of vitamin A in lowering risk of cataracts and age-related macular degeneration (ARMD) has been illustrated. Also, plausible role of fat-soluble vitamins in risk attenuation in cardiac diseases has been studied. This chapter also discusses the role of Vitamin D in the immune system and its potential impact on infectious diseases. It highlights that Vitamin D has a significant influence on both innate and adaptive immunity, affecting various immune cells. Vitamin D fosters immune tolerance by promoting regulatory T cells (Tregs) and suppresses inflammation by altering the type of T cells produced. It also enhances the function of immune cells like macrophages and dendritic cells. Moreover, Vitamin D is linked to infectious diseases, and there’s evidence suggesting it may play a role in combating conditions such as tuberculosis, respiratory infections, and influenza. However, randomized controlled trials have produced inconsistent results regarding the prophylactic use of Vitamin D for infectious diseases. The importance of avoiding Vitamin D toxicity has been discussed. Further research is needed to fully understand its role in infectious diseases. Finally, the chapter emphasizes the importance of informed decision-making when it comes to vitamin supplementation and dispelling common myths and misconceptions. © 2025 Elsevier B.V., All rights reserved.
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