Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells Publisher Pubmed



Shahhosseini R1 ; Pakmehr S2, 3 ; Elhami A2 ; Shakir MN4 ; Alzahrani AA5 ; Alhamdani MM6 ; Abosoda M7, 8, 9 ; Alsalamy A10 ; Mohammadidehcheshmeh M11 ; Maleki TE12 ; Saffarfar H13 ; Alikhiavi P14
Authors

Source: Clinical and Experimental Medicine Published:2025


Abstract

Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are the driving forces behind the spread of cancer cells. The emergence and development of liquid biopsy using rare CTCs as a minimally invasive strategy for early-stage tumor detection and improved tumor management is a promising advancement in recent years. However, before blood sample analysis and clinical translation, precise isolation of CTCs from patients’ blood based on their biophysical properties, followed by molecular identification of CTCs using single-cell multi-omics technologies is necessary to understand tumor heterogeneity and provide effective diagnosis and monitoring of cancer progression. Additionally, understanding the origin, morphological variation, and interaction between CTCs and the primary and metastatic tumor niche, as well as and regulatory immune cells, will offer new insights into the development of CTC-based advanced tumor targeting in the future clinical trials. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
Other Related Docs
6. Overview of Liquid Biopsy, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
13. Circulating Tumor Dna (Ctdna) in the Era of Personalized Cancer Therapy, Journal of Diabetes and Metabolic Disorders (2018)
17. Tumor Immunology, Clinical Immunology (2022)