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Mixinyeast: A Multicenter Study on Mixed Yeast Infections Publisher



Medina N1 ; Sotodebran JC1 ; Seidel D2, 3, 4 ; Akyar I5, 6 ; Badali H7 ; Barac A8 ; Bretagne S9, 10 ; Cag Y11, 12 ; Cassagne C13 ; Castro C14 ; Chakrabarti A15 ; Dannaoui E16 ; Cardozo C17 ; Garciarodriguez J18 Show All Authors
Authors
  1. Medina N1
  2. Sotodebran JC1
  3. Seidel D2, 3, 4
  4. Akyar I5, 6
  5. Badali H7
  6. Barac A8
  7. Bretagne S9, 10
  8. Cag Y11, 12
  9. Cassagne C13
  10. Castro C14
  11. Chakrabarti A15
  12. Dannaoui E16
  13. Cardozo C17
  14. Garciarodriguez J18
  15. Guitard J19
  16. Hamal P20
  17. Hoenigl M21
  18. Jagielski T22
  19. Khodavaisy S23
  20. Lo Cascio G24
  21. Martinezrubio MC25
  22. Meletiadis J26
  23. Munoz P27, 28
  24. Ochman E29
  25. Pelaez T30
  26. Balzola APA31
  27. Prattes J32
  28. Roilides E33
  29. De Pipaon MRP34
  30. Stauf R35, 36
  31. Steinmann J35, 36
  32. Suarezbarrenechea AI37
  33. Tejero R38
  34. Trovato L39, 40
  35. Vinuela L41
  36. Wongsuk T42
  37. Zak I43
  38. Zarrinfar H44
  39. Lassflorl C45
  40. Arikanakdagli S46
  41. Alastrueyizquierdo A1

Source: Journal of Fungi Published:2021


Abstract

Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epi-demiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe ac-counted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. © 2020 by the authors. Li-censee MDPI, Basel, Switzerland.
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