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Micrornas 29, 150, 155, 223 Level and Their Relation to Viral and Immunological Markers in Hiv-1 Infected Naive Patients Publisher



Moghoofei M1 ; Bokharaeisalim F1, 2 ; Esghaei M1 ; Keyvani H1 ; Honardoost M3 ; Mostafaei S4, 5 ; Ghasemi A6 ; Tavakoli A1 ; Javanmard D1 ; Babaei F7 ; Garshasbi S2 ; Monavari SH1
Authors

Source: Future Virology Published:2018


Abstract

Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of miRNAs involved in the pathogenesis of HIV infection and manipulating these miRNAs could lead to opening a new gate to HIV-1 infection control. © 2018 Future Medicine Ltd.
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