Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Candidemia Due to Candida Lambica in a Neutropenic Oncology Patient: A Rare Case Report Publisher



S Nami SANAM ; M Raeisi MORTAZA ; Z Ramezanalipour ZAHRA ; P Hassanpour PARVIZ
Authors

Source: Medical Mycology Case Reports Published:2025


Abstract

We report a rare case of Candida lambica candidemia in a 56-year-old male with acute myeloid leukemia undergoing intensive chemotherapy. Despite fluconazole prophylaxis, the patient developed persistent febrile neutropenia. Blood cultures grew yeast, later identified as C. lambica via ITS rDNA sequencing. Antifungal susceptibility testing revealed sensitivity to voriconazole and other antifungals resulting in clinical improvement following targeted therapy. This case highlights the growing clinical relevance of rare non-albicans candida species in immunocompromised hosts, the limitations of conventional diagnostics, and the importance of molecular tools and antifungal susceptibility testing in guiding effective treatment. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Molecular Diagnosis, Phylogenetic Analysis, and Antifungal Susceptibility Profiles of Candida Species Isolated From Neutropenic Oncological Patients, BMC Infectious Diseases (2023)
2. Clinical, Epidemiological, and Mycological Features of Patients With Candidemia: Experience in Two Tertiary Referral Centers in Iran, Current Medical Mycology (2022)
3. Microbial Epidemiology of Candidaemia in Neonatal and Paediatric Intensive Care Units at the Children's Medical Center, Tehran, Mycoses (2018)
Experts (# of related papers)
View all Related Experts
Sadegh Khodavaisy (6)
Mohammadreza Salehi (5)
Other Related Docs
4. Epidemiological Features of Nosocomial Candidaemia in Neonates, Infants and Children: A Multicentre Study in Iran, Mycoses (2020)
5. In Vitro Antifungal Susceptibility Profiles of Candida Albicans Complex Isolated From Patients With Respiratory Infections, Acta Medica Iranica (2016)
6. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
7. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
8. Identification of Uncommon Oral Yeasts From Cancer Patients by Maldi-Tof Mass Spectrometry, BMC Infectious Diseases (2018)
9. Genetic Diversity and Antifungal Susceptibility of Candida Albicans Isolated From Iranian Patients, Medical Mycology (2019)
10. Investigation of Erg11 Gene Expression Among Fluconazole-Resistant Candida Albicans: First Report From an Iranian Referral Paediatric Hospital, British Journal of Biomedical Science (2015)
11. Low Level of Antifungal Resistance of Candida Glabrata Blood Isolates in Turkey: Fluconazole Minimum Inhibitory Concentration and Fks Mutations Can Predict Therapeutic Failure, Mycoses (2020)
12. Mixinyeast: A Multicenter Study on Mixed Yeast Infections, Journal of Fungi (2021)
13. A Rare Case of Candida Albicans-Associated Meningitis; a Case Report Study, Clinical Infection in Practice (2025)
14. Candida Infection in the Intensive Care Unit: A Study of Antifungal Susceptibility Pattern of Candida Species in Milad Hospital, Tehran, Iran, Journal de Mycologie Medicale (2015)
15. Frequency of Candidemia and Associated Factors According to a Sample of Children Admitted to a Pediatric Medical Center in Iran, Open Public Health Journal (2025)
16. Epidemiology of Yeast Species Causing Bloodstream Infection in Tehran, Iran (2015-2017); Superiority of 21-Plex Pcr Over the Vitek 2 System for Yeast Identification, Journal of Medical Microbiology (2020)
17. Epidemiology and Outcomes of Candidemia in a Referral Center in Tehran, Caspian Journal of Internal Medicine (2019)
18. Azole Resistance in Candida Albicans Isolates From Oropharyngeal Candidiasis Is Associated With Erg11 Mutation and Efflux Overexpression, Jundishapur Journal of Microbiology (2022)
19. Comparative in Vitro Activities of Seven Antifungal Drugs Against Clinical Isolates of Candida Parapsilosis Complex, Journal de Mycologie Medicale (2020)
20. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)