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Generation of a Four-Class Attenuation Map for Mri-Based Attenuation Correction of Pet Data in the Head Area Using a Novel Combination of Ste/Dixon-Mri and Fcm Clustering Publisher Pubmed



Khateri P1 ; Saligheh Rad H1, 2 ; Jafari AH2, 3, 4 ; Fathi Kazerooni A1, 2 ; Akbarzadeh A1 ; Shojae Moghadam M3, 4 ; Aryan A5 ; Ghafarian P6, 7 ; Ay MR1, 2
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Source: Molecular Imaging and Biology Published:2015


Abstract

Purpose: The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. Procedures: MR images of the head area were acquired using STE and two-point Dixon sequences. μ-maps were derived from MRI images based on a fuzzy C-means (FCM) clustering method along with morphologic operations. Quantitative assessment was performed to evaluate generated MRI-based μ-maps compared to X-ray computed tomography (CT)-based μ-maps. Results: The voxel-by-voxel comparison of MR-based and CT-based segmentation results yielded an average of more than 95 % for accuracy and specificity in the cortical bone, soft tissue, and air region. MRI-based μ-maps show a high correlation with those derived from CT scans (R2 > 0.95). Conclusions: Results indicate that STE/Dixon-MRI data in combination with FCM-based segmentation yields precise MR-based μ-maps for PET attenuation correction in hybrid PET/MRI systems. © 2015, World Molecular Imaging Society.
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