Tp53 Hotspot Mutations in Astrocytoma

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Tp53 Hotspot Mutations in Astrocytoma Publisher

Abdollahi E¹ ; Nikkhah M² ; Taghizadeh E³

Source: Health Biotechnology and Biopharma Published:2019

Abstract

The aim of this project was to investigate the P53 gene mutations in exon 8 in the patients with astrocytoma type brain tumor. This was an in vitro study, in which the extraction of DNA from 30 samples of brain tissue was performed by phenol-chloroform protocols. After polymerase chain reaction (PCR) amplification of exon 8 of p53 genes, screening by single strand conformation polymorphism (SSCP) was performed to detect the shift. In this study, three malignant novel missense mutations in one sample with grade 4 of astrocytoma were detected. Also one synonymous mutation in grade 4 of astrocytoma was detected. The findings were indicated that mutations in exon 8 of the P53 gene mostly were in malignant astrocytoma brain tumor type, which is important in diagnosis and gene therapy of brain tumors. Copyright © 2018, Health Biotechnology and Biopharma. All rights reserved.

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Style	Citing Format
MLA	Abdollahi E, Nikkhah M, Taghizadeh E. "Tp53 Hotspot Mutations in Astrocytoma." Health Biotechnology and Biopharma, vol. 3, no. 1, 2019, pp. 38-45.
APA	Abdollahi E, Nikkhah M, Taghizadeh E (2019). Tp53 Hotspot Mutations in Astrocytoma. Health Biotechnology and Biopharma, 3(1), 38-45.
Chicago	Abdollahi E, Nikkhah M, Taghizadeh E. "Tp53 Hotspot Mutations in Astrocytoma." Health Biotechnology and Biopharma 3, no. 1 (2019): 38-45.
Harvard	Abdollahi E, Nikkhah M, Taghizadeh E (2019) 'Tp53 Hotspot Mutations in Astrocytoma', Health Biotechnology and Biopharma, 3(1), pp. 38-45.
Vancouver	Abdollahi E, Nikkhah M, Taghizadeh E. Tp53 Hotspot Mutations in Astrocytoma. Health Biotechnology and Biopharma. 2019;3(1):38-45.
BibTex	@article{ author = {Abdollahi E and Nikkhah M and Taghizadeh E}, title = {Tp53 Hotspot Mutations in Astrocytoma}, journal = {Health Biotechnology and Biopharma}, volume = {3}, number = {1}, pages = {38-45}, year = {2019} }
RIS	TY - JOUR AU - Abdollahi E AU - Nikkhah M AU - Taghizadeh E TI - Tp53 Hotspot Mutations in Astrocytoma JO - Health Biotechnology and Biopharma VL - 3 IS - 1 SP - 38 EP - 45 PY - 2019 ER -

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