Comparison of Blood Indices, Including Neutrophil-To-Lymphocyte Ratio (Nlr), Platelet-To-Lymphocyte Ratio (Plr), Mean Platelet Volume (Mpv), and Red Cell Distribution Width (Rdw), in Patients With Pulmonary Thromboembolism Versus Deep Vein Thrombosis in Hospitalized Patients Publisher



Asgari A ; Ziamanesh F ; Allameh SF ; Kazemizadeh H ; Zebardast J ; Daraei M
Source: Journal of Iranian Medical Council Published:2026

Abstract

Background: Venous Thromboembolism (VTE) is the most common preventable cause of death in hospitalized patients. Inflammatory conditions and blood cells play a direct role in the thrombosis process. This study aimed to investigate the effect of some blood indices on VTE. Methods: 141 patients with Pulmonary Thromboembolism (PTE) and 138 patients with Deep Vein Thrombosis (DVT) with standard diagnostic methods were assessed. The patients were hospitalized at Imam Khomeini Hospital Complex during 2018-2020. The analysis was performed by IBM SPSS version 22 software. Results: The mean rank of all the blood indices [Red Cell Distribution Width (RDW), Platelet-to-Lymphocyte Ratio (PLR), Mean Platelet Volume (MPV), and Neutrophil-to-Lymphocyte Ratio (NLR)] in the PTE group was higher than in the DVT group. But only NLR (p=0.00) and MPV (p=0.022) were significantly higher in patients with PTE. In the multivariate analysis, diabetes, NLR, and MPV indices were independently higher in the PTE group. Conclusion: NLR and MPV were independently and significantly higher in patients with PTE than in those with DVT, and they can indicate an increased likelihood of developing PTE in patients with DVT and lead to an early diagnosis of PTE. To improve the clinical application of these indices, further studies should be conducted to determine their normal range, sensitivity, and specificity with a large number of participants in multiple centers to accurately identify other conditions that affect these blood indices. Copyright 2026, Journal of Iranian Medical Council.