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Different Sars-Cov-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (Inrvd) Publisher



Razavi A ; Koltapeh MP ; Nazari T ; Morvaridi A ; Banivaheb B ; Saeb S ; Moulaeian M ; Zakaryaei A ; Sabzalian A ; Raei M ; Razavi B ; Motlaghzadeh S ; Hosseini SS ; Karami H Show All Authors
Authors
  1. Razavi A
  2. Koltapeh MP
  3. Nazari T
  4. Morvaridi A
  5. Banivaheb B
  6. Saeb S
  7. Moulaeian M
  8. Zakaryaei A
  9. Sabzalian A
  10. Raei M
  11. Razavi B
  12. Motlaghzadeh S
  13. Hosseini SS
  14. Karami H
  15. Ghafari P
  16. Aboofazeli A
  17. Nastarvand S
  18. Sarabi NKN
  19. Avakian A
  20. Ebadinejad S
  21. Keyhani T
  22. Danafar P
  23. Rahimlou R
  24. Heidarian S
  25. Mondeali M
  26. Nafemonfared F
  27. Jafarpour M
  28. Samiee M
  29. Birang F
  30. Mirzazadeh A
  31. Abadi SAF
  32. Barkhordari K
  33. Siavoshi S
  34. Biklari M
  35. Khodabakhsh M
  36. Javadi A
  37. Mirzaee S
  38. Didgar F
  39. Etebari M
  40. Soltanmohamad S
  41. Shahbaz B
  42. Kord E
  43. Shahri SMH
  44. Ebrahimzade M
  45. Moghaddam AA
  46. Sanavi FS
  47. Moattari A
  48. Edalat F
  49. Sheijani MF
  50. Moghadami M
  51. Yaghubi T
  52. Mojtahedi A
  53. Heidarzadeh A
  54. Naghipour M
  55. Luyeh MS
  56. Nazemi P
  57. Alipasandi K
  58. Albaji M
  59. Afzali M
  60. Shokouhi N
  61. Ezani A
  62. Najari HR
  63. Hosseini M
  64. Ghobadi A
  65. Momeni A
  66. Fattahi SZ
  67. Mohsenzadeh M
  68. Jafari M
  69. Azizi A
  70. Pouryousef S
  71. Tabarraei A
  72. Moradi A
  73. Azimi S
  74. Yahyapour Y
  75. Bayani M
  76. Poortahmasebi V
  77. Varshochi M
  78. Ziaee M
  79. Ghafari S
  80. Javanmard D
  81. Soleimani A
  82. Mozhgani SH
  83. Mokhames Z
  84. Akhoundimeybodi Z
  85. Astani A
  86. Abdollahi A
  87. Hadadi A
  88. Salehi MR
  89. Hajiabdolbaghi M
  90. Raeeskarami SR
  91. Kafan S
  92. Montazeri M
  93. Pazoki M
  94. Riahi T
  95. Talebitaher M
  96. Ataeipirkooh A
  97. Bokharaeisalim F
  98. Faiz SHR
  99. Kalantari S
  100. Yasin Z
  101. Jazayeri SM

Source: Health Science Reports Published:2026


Abstract

Background and Aims: This study aims to examine the prevalence and progression of coagulation disorders in adult COVID-19 patients and evaluate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on coagulation markers. Methods: This retrospective study included 1885 hospitalized COVID-19 patients, aged 20 to over 90 years, from January 23, 2020, to March 9, 2021, across 23 centers in 13 provinces in Iran. Patients were categorized into three epidemiological peaks corresponding to different pandemic waves and SARS-CoV-2 variants (wild-type, B.1.36, and B.1.1.413). Data collection and statistical analysis adhered to the Iranian Center for Disease Control guidelines, with laboratory assessments focusing on hematologic and coagulation markers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet (PLT) count, and Hemoglobin (Hb). Parameters were assessed to monitor coagulation dynamics and thrombotic risk over time and across epidemic waves. Estimated marginal means enabled evaluation of biomarker fluctuations by time and sex. Results: The majority of patients were below 70 years of age, with hypertension and diabetes as common underlying conditions. The study revealed a trend of increasing white blood cells, neutrophils, neutrophil-to-lymphocyte ratio, and PLTs during the initial week. Conversely, hemoglobin and lymphocytes exhibited a downward trend. PLT, lymphocyte, and neutrophil levels were not significantly affected by sex, age groups, or different peaks. Notably, hospitalized patients exhibited prolonged PT and aPTT. Overall, 81.1% of patients recovered, while 18.9% succumbed to the disease. Conclusion: This multicenter study provides valuable insights into the coagulation dynamics of COVID-19 patients, highlighting specific coagulation disorders associated with SARS-CoV-2. The findings emphasize the importance of monitoring coagulation markers for effective patient management and treatment decisions. Understanding how genetic and non-genetic factors influence outcomes is crucial for comprehensive care. Standardized data collection across centers strengthens the study's reliability. © 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
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