Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Differentiation of Human Endometrial Stem Cells Into Endothelial-Like Cells on Gelatin/Chitosan/Bioglass Nanofibrous Scaffolds Publisher Pubmed



Shamosi A1 ; Mehrabani D2, 3 ; Azami M1 ; Ebrahimibarough S1 ; Siavashi V4 ; Ghanbari H5 ; Sharifi E1 ; Roozafzoon R1 ; Ai J1, 6
Authors

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2016


Abstract

The capacity of gelatin/chitosan/bioactive glass nanopowders (GEL/CS/BGNPs) scaffolds was investigated for increasing human endometrial stem cells (hEnSCs) differentiation into the endothelial cells in the presence of angiogenic factors. GEL/CS nanofibrous scaffold with different contents of BGNPs were fabricated and assessed. Expression of endothelial markers (CD31, vascular endothelial cadherin (VE-cadherin), and KDR) in differentiated cells was evaluated. Results showed the diameter of nanofiber increases with decreasing the BG content in GEL/CS scaffolds. Moreover, in vitro study indicated that the GEL/CS/BGNPs scaffold with 1.5% BGNPs content provided a suitable three-dimensional structure for endothelial cells differentiation. Thus, the GEL/CS/BGNPs scaffold can be recommended for blood vessels repair. © 2016 Taylor & Francis.
Other Related Docs