The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies

The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies Publisher Pubmed

Zalpoor H^{1, 2, 3} ; Akbari A⁴ ; Samei A⁵ ; Forghaniesfidvajani R⁴ ; Kamali M⁶ ; Afzalnia A⁶ ; Manshouri S⁶ ; Heidari F⁷ ; Pornour M⁸ ; Khoshmirsafa M⁹ ; Aazami H¹⁰ ; Seif F^{2, 11}

Source: Cellular and Molecular Biology Letters Published:2022

Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases. © 2022, The Author(s).

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Nima Rezaei (3)

Shadi Sadat Seyyedebrahimi (1)

Style	Citing Format
MLA	Zalpoor H, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters, vol. 27, no. 1, 2022, pp. -.
APA	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, Heidari F, Pornour M, Khoshmirsafa M, Aazami H, Seif F (2022). The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters, 27(1), -.
Chicago	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters 27, no. 1 (2022): -.
Harvard	Zalpoor H et al. (2022) 'The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies', Cellular and Molecular Biology Letters, 27(1), pp. -.
Vancouver	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, et al.. The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters. 2022;27(1):-.
BibTex	@article{ author = {Zalpoor H and Akbari A and Samei A and Forghaniesfidvajani R and Kamali M and Afzalnia A and Manshouri S and Heidari F and Pornour M and Khoshmirsafa M and Aazami H and Seif F}, title = {The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies}, journal = {Cellular and Molecular Biology Letters}, volume = {27}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zalpoor H AU - Akbari A AU - Samei A AU - Forghaniesfidvajani R AU - Kamali M AU - Afzalnia A AU - Manshouri S AU - Heidari F AU - Pornour M AU - Khoshmirsafa M AU - Aazami H AU - Seif F TI - The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies JO - Cellular and Molecular Biology Letters VL - 27 IS - 1 SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Zalpoor H, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters, vol. 27, no. 1, 2022, pp. -.

APA

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, Heidari F, Pornour M, Khoshmirsafa M, Aazami H, Seif F (2022). The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters, 27(1), -.

Chicago

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters 27, no. 1 (2022): -.

Harvard

Zalpoor H et al. (2022) 'The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies', Cellular and Molecular Biology Letters, 27(1), pp. -.

Vancouver

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, et al.. The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters. 2022;27(1):-.

BibTex

@article{ author = {Zalpoor H and Akbari A and Samei A and Forghaniesfidvajani R and Kamali M and Afzalnia A and Manshouri S and Heidari F and Pornour M and Khoshmirsafa M and Aazami H and Seif F}, title = {The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies}, journal = {Cellular and Molecular Biology Letters}, volume = {27}, number = {1}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Zalpoor H
AU - Akbari A
AU - Samei A
AU - Forghaniesfidvajani R
AU - Kamali M
AU - Afzalnia A
AU - Manshouri S
AU - Heidari F
AU - Pornour M
AU - Khoshmirsafa M
AU - Aazami H
AU - Seif F
TI - The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies
JO - Cellular and Molecular Biology Letters
VL - 27
IS - 1
SP -
EP -
PY - 2022
ER -

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