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Complement System As the Potential Therapeutic Target in the Management of Covid-19 Patients Publisher



Parsamanesh G1 ; Farhangnia P2, 3, 4 ; Karimi M2 ; Ghomi AK2 ; Dehrouyeh S2 ; Aghamajidi A2
Authors

Source: Trends in Immunotherapy Published:2022


Abstract

The emerging COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been raised as a global health challenge. Despite the breakthrough in the development of the COVID-19 vac-cine, it still continues as a serious crisis, worldwide. The aberrant immune responses are strongly associated with the severity of the disease and an increased rate of morbidity and mortality among COVID-19 patients. The complement cascade activation is mediated by classical, lectin, and alternative pathways which could induce an inflammatory state during the COVID-19 infection. The growing body of research suggests that complement system activation plays an important role in the immunopathogenesis of SARS-CoV-2. Therefore, the blockade of complement cascades may be an effective approach to prevent the multi-organ complications of COVID-19. In this review, we will highlight the role of the complement system in the immunopathology of COVID-19, emphasizing the potential therapeutical targets to ameliorate COVID-19 infection. © 2022 Gilda Parsamanesh, et al.
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