Cellulose-Based Nanofibril Composite Materials As a New Approach to Fight Bacterial Infections Publisher



Rashki S¹ ; Shakour N^{2, 3} ; Yousefi Z⁴ ; Rezaei M⁵ ; Homayoonfal M⁶ ; Khabazian E⁷ ; Atyabi F^{7, 8} ; Aslanbeigi F^{9, 10} ; Safaei Lapavandani R¹¹ ; Mazaheri S¹² ; Hamblin MR¹³ ; Mirzaei H⁶
Source: Frontiers in Bioengineering and Biotechnology Published:2021

Abstract

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections. Copyright © 2021 Rashki, Shakour, Yousefi, Rezaei, Homayoonfal, Khabazian, Atyabi, Aslanbeigi, Safaei Lapavandani, Mazaheri, Hamblin and Mirzaei.