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Hematopoietic Stem Cell Transplantation and Lymphodepletion for the Treatment of Cancer Publisher



Barr KM1 ; Khoshbin AP2, 3 ; Gershan JA4 ; Johnson BD5
Authors

Source: Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition Published:2020


Abstract

Hematopoietic stem cell transplantation (HSCT) can be an effective treatment for hematologic malignancies and, more recently, has shown efficacy for the treatment of solid tumors. Myeloablative, reduced-intensity, or non-myeloablative conditioning serves to eliminate or reduce the number of malignant cells, create space in the hematopoietic compartment for the expansion of transplanted hematopoietic cells, and provide a hematopoietic environment that is conducive to the proliferation of antitumor immune cells. Discussed in this chapter are an overview of HSCT, different sources of hematopoietic stem cells (HSC), treatments used to deplete hematopoietic cells and/or induce lymphodepletion, how these treatments are used as preconditioning for autologous and allogeneic HSCT, and how lymphodepletion augments an antitumor immune response during hematopoietic cell reconstitution. © Springer Nature Switzerland AG 2015, 2021. All rights reserved.
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