Longevity of Immunity Following Covid-19 Vaccination: A Comprehensive Review of the Currently Approved Vaccines Publisher Pubmed



Jamshidi E¹ ; Asgary A² ; Shafiekhani P³ ; Khajeamiri Y⁴ ; Mohamed K^{5, 6} ; Esmaily H⁴ ; Jamal Rahi S⁷ ; Mansouri N^{8, 9, 10}
Source: Human Vaccines and Immunotherapeutics Published:2022

Abstract

It is unknown how long the immunity following COVID-19 vaccination lasts. The current systematic review provides a perspective on the persistence of various antibodies for available vaccines.Both the BNT162b2 and the mRNA-1273 induce the production of IgA antibodies, reflecting the possible prevention of the asymptomatic spread. The mRNA-1273 vaccineʻs antibodies were detectable until 6 months, followed by the AZD1222, 3 months, the Ad26.COV2.S and the BNT162b2 vaccines within 2 months.The BNT162b2 produced anti-spike IgGs 11 days after the first dose and peaked at day 21, whereas the AZD1222 induced a neutralizing effect 22 days after the first dose.These vaccines induce T-cell mediated immune responses too. Each one of the AZD1222, Ad26.COV2.S, mRNA-1273 mediates T-cell response immunity at days 14-22, 15, and 43 after the first dose, respectively. Whereas for the BNT162b1 and BNT162b2 vaccines, T-cell immunity is induced 7 days and 12 weeks after the booster dose, respectively. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.