Breakthrough Sars-Cov-2 Infections After Vaccination: A Critical Review Publisher Pubmed



Mohseni Afshar Z¹ ; Barary M^{2, 3} ; Hosseinzadeh R⁴ ; Alijanpour A⁵ ; Hosseinzadeh D⁶ ; Ebrahimpour S⁷ ; Nazary K⁴ ; Sio TT⁸ ; Sullman MJM^{9, 10} ; Carsonchahhoud K¹¹ ; Babazadeh A⁷
Source: Human Vaccines and Immunotherapeutics Published:2022

Abstract

At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.