Synthesis of a New 1,2,3-Triazoles Scaffold Using a Heterogeneous Multifunctional Copper Photocatalyst for in Vitro Investigation Via Click Reaction Publisher

Summary: Can a new catalyst fight Alzheimer’s? Research shows a magnetic photocatalyst creates anti-Alzheimer compounds efficiently, offering a sustainable drug-making method. #AlzheimersResearch #Nanochemistry

Mohammadkhani A¹ ; Hosseini S^{2, 4} ; Pourmousavi SA² ; Heydari A¹ ; Mahdavi M³
Source: Catalysis Science and Technology Published:2024

Abstract

In this work, a new ternary-layered double-hydroxide photocatalyst, denoted as Fe3O4/AlZn-Cu, was synthesized using a specific 6.5 : 3 : 7.5 : 1.5 mol mol−1 ratio. The rational selection of constituents in this catalyst - Fe3O4 for bulk and electron richness effect, AlZn LDH for supporting the photo redox process, and copper as an active site - is thoroughly elucidated. This paper comprehensively investigates the synthesis and characterizes the properties of this magnetic ternary-layered double-hydroxide heterogeneous multifunctional photocatalyst. Several key scientific domains are explored within this study: (i) demonstrating the catalyst's efficacy in synthesizing 1,2,3-triazoles N-acetamide as an active biological candidate; (ii) synthesize a 1,2,3-triazole scaffold in a benign and ambient environment, having biologically active properties (iii) a comprehensive analysis of the catalyst's structural, optical, and electrochemical properties; and (iv) evaluating the potential of newly structured drug candidates, integrating two anti-Alzheimer heterocyclic moieties linked through click chemistry, through in vitro assessment. Employing insights from biorthogonal chemistry, this study establishes a link between two distinct active Alzheimer-targeting biological moieties via click chemistry, obviating the need for organic ligands, photosensitizers, and additives. Furthermore, the multifunctional photocatalyst proves to be cost-effective, robust, and recyclable. The stability of the Fe3O4/AlZn-Cu structure allows for efficient recyclability, facilitated by magnetic recovery techniques, demonstrated effectively over five cycles. Extensive analysis of the recycled catalyst is conducted, affirming its potential for sustainable applications. © 2024 The Royal Society of Chemistry.