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Magnetic Silica Nanoparticle-Supported Copper Complex As an Efficient Catalyst for the Synthesis of Novel Triazolopyrazinylacetamides With Improved Antibacterial Activity Publisher



Asgari MS1, 3 ; Sepehri S2 ; Bahadorikhalili S1 ; Ranjbar PR1 ; Rahimi R3 ; Gholami A4 ; Kazemi A4, 5 ; Khoshneviszadeh M4 ; Larijani B6 ; Mahdavi M6
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Source: Chemistry of Heterocyclic Compounds Published:2020


Abstract

[Figure not available: see fulltext.] A novel superparamagnetic iron oxide modified with copper via 2-aminobenzamide is synthesized by the modification of Fe3O4@SiO2 with amine, followed by the reaction with isatoic anhydride. The catalyst is fully characterized by various methods. The catalytic activity of the catalyst is evaluated in the synthesis of a series of novel N-alkyl-2-aryl-2-(6-oxo-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)acetamide analogs. Antibacterial activity of the synthesized compounds is evaluated. The catalyst is recoverable and shows excellent reusability in 10 sequential runs. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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