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Combined Therapy of Adipose-Derived Stem Cells and Photobiomodulation on Accelerated Bone Healing of a Critical Size Defect in an Osteoporotic Rat Model Publisher Pubmed



Asgari M1 ; Gazor R2 ; Abdollahifar MA1 ; Fadaei Fathabady F1 ; Zare F1 ; Norouzian M1 ; Amini A1 ; Khosravipour A1 ; Kiani P3 ; Atashgah RB4 ; Rezaei F5 ; Ghoreishi SK6 ; Chien S7 ; Hamblin MR8, 9 Show All Authors
Authors
  1. Asgari M1
  2. Gazor R2
  3. Abdollahifar MA1
  4. Fadaei Fathabady F1
  5. Zare F1
  6. Norouzian M1
  7. Amini A1
  8. Khosravipour A1
  9. Kiani P3
  10. Atashgah RB4
  11. Rezaei F5
  12. Ghoreishi SK6
  13. Chien S7
  14. Hamblin MR8, 9
  15. Bayat M1, 7

Source: Biochemical and Biophysical Research Communications Published:2020


Abstract

We investigated the impact of human demineralized bone matrix (hDBM) plus adipose-derived stem cells (hADS) plus photobiomodulation (PBM) on a critical-sized femoral defect (CSFD) in ovariectomy induced osteoporosis in rats. There were 6 groups as follows. In group 1 (control, C), only CSFDs were created. Groups 2–6 were implanted with DBM into the CSFD (DBM-CSFD). In group 2 (S), only DBM was transplanted into the CSFD. In group 3 (S + PBM), the DBM-CSFDs were treated with PBM. In group 4, the DBM-CSFDs were treated with alendronate (S + ALN). In group 5, ADSs were seeded into DBM-CSFD (S + ADS). In group 6, ADSs were seeded into DBM-CSFD and the CSFDs were treated with PBM (S + PBM + ADS). At week eight (catabolic phase of bone repair), the S + ALN, S + PBM + ADS, S + PBM, and S + ADS groups all had significantly increased bone strength than the S group (ANOVA, p = 0.000). The S + PBM, S + PBM + ADS, and S + ADS groups had significantly increased Hounsfield unit than the S group (ANOVA, p = 0.000). ALN, ADS, and PBM significantly increased healed bone strength in an experimental model of DBM-treated CSFD in the catabolic phase of bone healing in osteoporotic rats. However, ALN alone and PBM plus ADS were superior to the other protocols. © 2020 Elsevier Inc.
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