The Association Between Blood Vitamins D and E With Age-Related Macular Degeneration: A Pilot Study Publisher



Hashemi R¹ ; Bandarian M² ; Abeditaleb E³ ; Khojasteh H⁴ ; Khedmat L^{5, 6} ; Asadollahi E³ ; Beytollahi M⁷ ; Jelodar AM⁸
Source: Interventional Medicine and Applied Science Published:2018

Abstract

Background: This study was aimed to evaluate the association of serum vitamins D and E level with age-related macular degeneration(AMD). Methods: This pilot study was performed in two groups of 15 patients in treatment group and 15 patients in control group. Measurements ofblood factors [such as C-reactive protein (CRP) and high-density lipoprotein (HDL)] were performed after 12 h of fasting. To measure vitamins Dand E, the serum was isolated from 5 cc blood samples. Results: HDL was higher in the control group as compared with the AMD group. However,no significant difference was found between the two groups (p = 0.08). On the other hand, serum vitamin E in the AMD group was remarkably higheras compared to the control group (p < 0.002). However, no significant difference was found in serum vitamin D levels between the two groups(p = 0.662). Our findings also revealed that there was no statistically significant relationship between BMI and AMD. Moreover, no significantcorrelation was determined between serum CRP and AMD (p = 0.96). Conclusions: Our data indicated that none provides evidence for associationsbetween AMD and serum vitamin D levels. The association between vitamin D and AMD requires further investigations in a large population studies,to elucidate whether vitamin D deficiency can be an important risk factor for AMD. © 2018 The Author(s).