Relationship Between Serum 25-Hydroxyvitamin D Level and Preeclampsia Components and Metabolic Parameters Among Overweight or Obese Pregnant Women Publisher



Dolati S¹ ; Mohammadi A^{2, 3} ; Onsoroudi AB^{2, 3} ; Sadeghian S⁴ ; Haghighi SN⁵ ; Foroumandi E⁶ ; Jafarvand E⁷
Source: Ethiopian Journal of Reproductive Health Published:2024

Abstract

BACKGROUND: Studies have shown that vitamin D deficiency can be related to the occurrence of preeclampsia. OBJECTIVE: The present study was conducted with the aim of determining the relationship between the serum level of 25-hydroxyvitamin D and preeclampsia and its related risk factors among obese or overweight pregnant women. METHODS: This cross-sectional-analytical study was conducted on 83 pregnant obese or overweight women referred to comprehensive health service centers in Makoo city. Anthropometric indices and biochemical factors including vitamin D serum level, glycemic indices and lipid parameters were investigated in these women. In addition, the food intake of the participants was evaluated using an Food Frequency Questionnaire (FFQ). RESULTS: The results showed that there is a direct correlation between vitamin D serum level and dietary fat level (r=0.269, p=0.007) and high-density lipoprotein (HDL-C) (r=0.478, p<0.0001). Also, there was an inverse correlation between serum vitamin D level and pre-pregnancy body mass index (r=-0.625, p<0.0001), systolic blood pressure (r=-0.592, p<0.0001), diastolic blood pressure (r=-0.592, p<0.0001), fasting blood sugar (FBS) (r=-0.511, p<0.0001), proteinuria (r=-0.422, p<0.0001), triglyceride (TG) (r=-0.36, p = 0.011), total cholesterol(TC) (r=-0.428, p<0.0001) and low-density lipoprotein (LDL-C) (r=-0.602, p<0.0001). CONCLUSION: There is a direct relationship between dietary fat intake and serum vitamin D level. There is also a positive correlation between serum levels of this vitamin and serum HDL-C. On the other hand, there is an inverse relationship between the serum level of vitamin D and systolic blood pressure, degree of proteinuria, pre-pregnancy body mass index and fasting blood sugar total cholesterol and low-density lipoprotein . © 2024 Ethiopian Society of Obstetricians and Gynecologists (ESOG). All rights reserved.