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Micrornas Signatures, Bioinformatics Analysis of Mirnas, Mirna Mimics and Antagonists, and Mirna Therapeutics in Osteosarcoma Publisher



Otoukesh B1, 2 ; Abbasi M3 ; Gorgani HOL2 ; Farahini H2 ; Moghtadaei M2 ; Boddouhi B2 ; Kaghazian P4 ; Hosseinzadeh S5 ; Alaee A6
Authors

Source: Cancer Cell International Published:2020


Abstract

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted. © 2020 The Author(s).
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