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Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators Publisher Pubmed



Zadali R1, 2, 3 ; Nejadebrahimi S4 ; Hadjiakhoondi A2, 5 ; Fiengo L1 ; Dambola M1 ; De Vita S1 ; Tofighi Z2, 5 ; Chini MG1, 6 ; Bifulco G1 ; De Tommasi N1
Authors

Source: Phytochemistry Published:2021


Abstract

Four undescribed and 17 known diterpenoids were isolated from the roots of Zhumeria majdae Rech.f. & Wendelbo. Using 1D and 2D NMR spectroscopy, ECD spectroscopy, and HRESIMS data analysis, the structures of the undescribed compounds were elucidated. The anti-proliferative activity of isolated compounds was evaluated against HeLa and MCF7 cancer cell lines. The binding affinity of all compounds to HSP90, one of the targets for the modern anticancer therapy, was investigated using surface plasmon resonance. The results demonstrated that lanugon Q interacted with the chaperone. To explain its mechanism of action, experimental and computational tests were also conducted. © 2021 Elsevier Ltd
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