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Cytotoxic Abietane Diterpenoids From Salvia Leriifolia Benth Publisher Pubmed



Sarhadi E1 ; Nejad Ebrahimi S2 ; Hadjiakhoondi A1, 3 ; Abbasmohammadi M4 ; Manayi A1 ; Parisi V5 ; Pessolano E5 ; Petrella A5 ; De Tommasi N5
Authors

Source: Phytochemistry Published:2022


Abstract

The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 ± 0.6 and 14.38 ± 1.4 μM. © 2022 Elsevier Ltd
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